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KMID : 0985420120340020077
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Laboratory Medicine and Quality Assurance
2012 Volume.34 No. 2 p.77 ~ p.86
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Evaluation of the Dimension Vista 1500 Chemical Autoanalyzer
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Lee Dong-Hyun
Yoon Kap-Jun
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Abstract
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Background: Laboratory tasks involve the analysis of a large number of specimens and generation of accurate results in a short period of time. The Dimension Vista 1500 (Siemens, Germany), an automated chemistry analyzer, has been introduced in our hospital to improve the efficiency of laboratory analysis. In order to assess the performance and usability of the analyzer, we evaluated its analytical performance and clinical usefulness, and compared these factors to those of the formerly used Modular DP analyzer (Roche Diagnostics, USA), Vitros 5.1 FS analyzer (Ortho Clinical Diagnostics, USA), and ADVIA Centaur analyzer (Siemens). Methods: The accuracy, linearity, recovery factor, and sample carryover of the Dimension Vista 1500 analyzer were determined for 19 routine, immunochemistry, and cardiac marker tests (blood urea nitrogen, creatinine, glucose, calcium, phosphorus, total protein, albumin, AST, ALT, gamma-glutamyl transferase, creatine kinase [CK], lactate dehydrogenase, alkaline phosphatase, total bilirubin, high -sensitivity C-reactive protein, CK-MB, cardiac troponin I [cTnI], myoglobin, B-type natriuretic peptide), and values obtained for Modular DP, ADVIA centaur, and Vitros 5.1 FS analyzers were used to make comparisons. Results: The coefficient of variation (CV) showed excellent values of ≤5% for all tests except for ALT, when it was tested by using low level pooled serum material. The coefficient of determination (R2) was ≥0.996 with excellent linearity between 0.99 and 1.02. In addition, the recovery factor values of the tests were 88-107%, and percentage sample carryover values of the tests were ≤1%, suggesting that the results of the tests were not affected by sample carryover. The Pearson correlation coefficients (r) between the Modular DP, ADVIA centaur, Vitros 5.1 FS, and Dimension Vista 1500 analyzers for all tests were ≥0.96, except for cTnI (0.935), and showed good correlation (P<0.001). Conclusions: The Dimension Vista 1500 analyzer showed good analytical performance (linearity, precision, and accuracy) for 15 routine chemistry and 4 cardiac marker tests. Furthermore, results from the tests performed on the Dimension Vista 1500 analyzer correlated well with those obtained from similar tests performed on the Modular DP, ADVIA centaur, and Vitros 5.1 FS analyzers. Therefore, the Dimension Vista 1500 analyzer is appropriate for a tertiary care hospital where large volumes of tests have to be processed within a short period of time.
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KEYWORD
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Dimension Vista 1500 analyzer, Chemistry analyzer, Analytical performance, Autoanalyzer
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